Medication-assisted treatment (MAT) is a combination of medication and counseling to treat opioid use disorders. It is one of the most effective treatments available, and the FDA has approved three drugs for MAT: buprenorphine, methadone, and naltrexone. All three drugs are safe and effective when used with counseling and psychosocial support. It is recommended that all people seeking treatment for opioid use disorder be offered access to all three MAT options.